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Results Found: 4
  • Myelodysplastic (MSKCC, 2020): Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms

    Description

    This dataset contains the summary data visualizations and clinical data from 4,231 myeloid neoplasm samples from 4,231 patients. Clinical data includes: Cancer Type, Cancer Type Detailed, Mutation Count, Oncotree Code, Sequencing Type, Somatic Status, Study. The plaintext components of the dataset can be downloaded as a tar file. The clinical data can be downloaded as a tsv file.

    Subject
    Acute monoblastic/monocytic leukemia
    Anemia, Refractory
    Anemia, Refractory, with Excess of Blasts
    Anemia, Sideroblastic
    Leukemia, Erythroblastic, Acute
    Leukemia, Megakaryoblastic, Acute
    Leukemia, Myelogenous, Chronic, BCR-ABL Positive
    Leukemia, Myeloid, Acute
    Leukemia, Myelomonocytic, Acute
    Leukemia, Myelomonocytic, Chronic
    Mastocytosis
    Myelodysplastic Syndromes
    Myelodysplastic-Myeloproliferative Diseases
    Oncogene Proteins, Fusion
    Polycythemia Vera
    Primary Myelofibrosis
    Sarcoma, Myeloid
    Thrombocythemia, Essential
    Access Rights
    Free to All
    Local Expert
    Papaemmanuil, Elli
  • Cellular states, clonal dynamics, and evolution in Pearson syndrome revealed via single-cell multi-omics [Celline_scATAC]

    Authors
    Lareau, Caleb A.
    Ludwig, Leif S.
    Description

    Summary from GEO: "Large deletions in mitochondrial DNA (mtDNA) have been linked to a variety of clinical pathologies, including somatic emergence in congenital disorders such as Pearson Syndrome (MIM:557000), a mitochondrial disease characterized by sideroblastic anemia and exocrine pancreas dysfunction. Here, we develop a multi-omics approach to quantify mtDNA deletion heteroplasmy and cell state...

    Subject
    Anemia, Sideroblastic
    Binding sites
    Fibroblasts
    Genomics
    Heteroplasmy/genetics
    Myelodysplastic Syndromes
    Single-Cell Analysis
    Access Rights
    Free to All
  • Cellular states, clonal dynamics, and evolution in Pearson syndrome revealed via single-cell multi-omics [PBMC_scRNA]

    Authors
    Lareau, Caleb A.
    Ludwig, Leif S.
    Description

    Summary from GEO: "Large deletions in mitochondrial DNA (mtDNA) have been linked to a variety of clinical pathologies, including somatic emergence in congenital disorders such as Pearson Syndrome (MIM:557000), a mitochondrial disease characterized by sideroblastic anemia and exocrine pancreas dysfunction. Here, we develop a multi-omics approach to quantify mtDNA deletion heteroplasmy and cell state...

    Subject
    Anemia, Sideroblastic
    Gene Expression Profiling
    Genomics
    Heteroplasmy/genetics
    Leukocytes, Mononuclear
    Myelodysplastic Syndromes
    Single-Cell Analysis
    Access Rights
    Free to All
  • Cellular states, clonal dynamics, and evolution in Pearson syndrome revealed via single-cell multi-omics [PBMC_scATAC]

    Authors
    Lareau, Caleb A.
    Ludwig, Leif S.
    Description

    Summary from GEO: "Large deletions in mitochondrial DNA (mtDNA) have been linked to a variety of clinical pathologies, including somatic emergence in congenital disorders such as Pearson Syndrome (MIM:557000), a mitochondrial disease characterized by sideroblastic anemia and exocrine pancreas dysfunction. Here, we develop a multi-omics approach to quantify mtDNA deletion heteroplasmy and cell state...

    Subject
    Anemia, Sideroblastic
    Binding sites
    Genomics
    Heteroplasmy/genetics
    Leukocytes, Mononuclear
    Myelodysplastic Syndromes
    Single-Cell Analysis
    Access Rights
    Free to All